Endosalpingiosis linked with increased risk of cancer risk compared to endometriosis

This is a retrospective case-control analysis of patients with a histologic diagnosis of endosalpingiosis or endometriosis at three affiliated academic hospitals between 2000 and 2020. All endosalpingiosis patients were included, and 1:1 matching was attempted to obtain a comparable cohort of endometriosis patients. Demographic and clinical data were obtained, and statistical analysis was performed.

The results of the study are:

• A total of 967 patients (515 ES and 452 EM) were included.
• Endosalpingiosis patients were significantly older than endometriosis patients.
• The endosalpingiosis group had significantly more cancer diagnoses at surgery than the endometriosis group; this difference persisted in a sub-analysis excluding patients with known or suspected malignancy.
• Endosalpingiosis patients had lower overall survival.
• After adjusting for confounders, multivariable analysis showed that endosalpingiosis patients had increased cancer diagnosed at surgery and greater risk of death.

Thus, endosalpingiosis was found concurrently with malignancy in 40% of cases, and this effect was preserved in multi-variable and sub-group analyses. Further research consisting of longer follow-up and exploration of molecular relationships between endosalpingiosis and cancer are forthcoming.

Reference:

Gregory K. Lewis et al. The association of endosalpingiosis with gynecologic malignancy Published: July 28, 2022 DOI: https://doi.org/10.1016/j.ygyno.2022.07.025