Exposure to TNF- alfa inhibitors during pregnancy not tied to reduced risk of preeclampsia: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-05-10 14:15 GMT | Update On 2024-05-11 08:15 GMT

Exposure to TNF-alfa inhibitors during pregnancy was not tied to reduced risk of preeclampsia suggests a study published in the Journal of Hypertension.

Although the clinical importance of preeclampsia is widely recognized, few treatment options are available for prevention. TNF-α inhibitors have been hypothesized to potentially prevent the disease. They aimed to examine whether exposure to TNF-α inhibitors during pregnancy reduces the risk of preeclampsia. They conducted a population-based pregnancy cohort study using nationwide samples of publicly (Medicaid data, 2000-2018) and commercially (MarketScan Research Database, 2003-2020) insured pregnant women linked to their liveborn infants. Exposure was ascertained based on a filled prescription or administration code for TNF-α inhibitors during the first and second trimester of pregnancy. The outcomes included early-onset preeclampsia, late-onset preeclampsia, and small-for-gestational age. For baseline confounding adjustment, we leveraged propensity score overlap weights to estimate risk ratios (RR).

RESULTS: Among 4 315 658 pregnancies in the Medicaid and the MarketScan cohort, 2736 (0.063%) were exposed to TNF-α inhibitors during the first trimester and 1712 (0.040%) during the second trimester. After adjustment, the risk of early-onset preeclampsia was not decreased among mothers exposed during the first trimester compared with unexposed women with treatment indications [RRpooled: 1.25, 95% confidence interval (CI) 0.93-1.67]. Similarly, the risk of late-onset preeclampsia was not decreased among mothers exposed during the second trimester compared with unexposed women (RRpooled: 0.99, 95% CI 0.81-1.22). Contrary to the hypothesis, exposure to TNF-α inhibitors during pregnancy did not appear to be associated with a reduced risk of early-onset or late-onset preeclampsia. These findings do not support consideration of the use of TNF-α inhibitors for the prevention of preeclampsia.

Reference:

Adomi, Motohiko, et al. "TNF-α Inhibitor Use During Pregnancy and the Risk of Preeclampsia: Population-based Cohort Study." Journal of Hypertension, 2024.

Article Source : Journal of Hypertension

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Exposure to TNF- alfa inhibitors during pregnancy not tied to reduced risk of preeclampsia: Study

Similar News

A diet rich in vegetable protein and fiber helps maternal and infant health during pregnancy and breastfeeding: Study

Female Veterans with Lupus or Rheumatoid Arthritis Have Higher Pregnancy Risks, Finds Study

Pre-conception radiation exposure from CT scans increases risk for miscarriage and birth defects: Study

Myo-Inositol Does Not Reduce Pregnancy Risks in PCOS: JAMA

Adolescent Dysmenorrhoea Raises Risk of Chronic Pain in Adulthood, suggests study

First-Trimester Neutrophil Counts Not Useful for GDM Prediction: Study

Women With Pre-Pregnancy Chronic Conditions Face Greater Risk of Severe Maternal Complications: Study Shows

Why male embryos grow faster: Study reveals genetic clues