Oral glibenclamide as good as insulin for treatment of gestational diabetes mellitus
Iran: Insulin is the first-line treatment for gestational diabetes mellitus (GDM), but oral hypoglycemic agents are cheaper and easier to use. A recent study published in Obstetric Medicine has compared the effects of oral glibenclamide with subcutaneous insulin on perinatal outcomes of GDM patients.
Azam Faraj, IranShiraz University of Medical Sciences, Iran, and colleagues showed oral glibenclamide to be as safe and effective as subcutaneous insulin in maternal and neonatal outcomes and glycemic control in women with gestational diabetes. Thus, the research team suggests that it could be used as a first-line treatment of GDM.
In the study, the research team aimed to compare the safety and efficacy of oral glibenclamide and subcutaneous insulin on the serum glucose control and perinatal outcome of women with gestational diabetes mellitus in a randomized clinical trial.
The trial was conducted for 2 years from 2017 to 2019 in two tertiary healthcare centres in Shiraz, Iran. The researchers included 84 singleton pregnancies between 24 and 34 weeks of gestation diagnosed with gestational diabetes mellitus. They were randomly assigned to subcutaneous insulin (n = 40) or oral glibenclamide (n = 44) according to a standard protocol and followed until delivery.
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