Women with elderly obese partners at higher risk of embryo implantation failure
Over the past three decades, the age that couples in developed countries choose to have children has been rising steadily. This trend has become so pervasive that demographers have coined a term for it - postponement transition.
However, as fertility declines with age, older couples often find it harder to start a family. Some require medical support to conceive and successfully carry a baby full term. In a paper published in the KeAi journal Gynecology and Obstetrics Clinical Medicine, a group of researchers in China explored the effects of advanced paternal age (APA) and abnormal paternal weight (obesity) on in vitro fertilisation (IVF) treatment in nearly 800 couples who have experienced unexplained recurrent pregnancy loss (uRPL). Specifically, they considered the impact on embryo implantation, embryo quality and the health of the baby.
Corresponding author Junhao Yan, of Shandong University, explains: "While the effects of advanced maternal age (AMA) and maternal obesity on reproduction have been widely studied, investigations into the effects of APA and paternal weight are less common. This may be, in part, because the definition of APA is still up for debate - most studies set the age at between 40 and 50 years."
The 779 couples the team recruited had undergone their first preimplantation genetic testing for aneuploidies (PGT-A) cycles – this information was invaluable in helping the researchers single out the impact of APA and paternal obesity.
https://www.sciencedirect.com/science/article/pii/S2667164621000506?via%3Dihub
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