Women with Endometriosis and uterine fibroids likely to have Premature death, suggests study

A new study published in the British Medical Journal showed that women who have a history of uterine fibroids and endometriosis may be more likely to die young after they have finished having children. With clinically significant prevalences of 10% and 15% to 30%, respectively, endometriosis and uterine fibroids are prevalent conditions among women in their reproductive years.

Growth of endometrial-like tissue outside the uterus is a hallmark of endometriosis. Uterine fibroids, on the other hand, are smooth muscle cell-based, non-cancerous tumors that usually develop inside or near the myometrium. But uterine fibroids and endometriosis have similar genetic roots, and they grow through a combination of proinflammatory, immunological, and endocrine mechanisms. As a result, Yi-Xin Wang looked at how endometriosis and uterine fibroids affected the long-term risk of premature death in women from the Nurses' Health Study II (NHSII), which has been conducted every two years for 30 years in the United States.

In 1989, 110,091 women between the ages of 25 and 42 who had never had a hysterectomy previously were diagnosed with cancer, cardiovascular disease, or endometriosis or fibroids were included. The key performance indicators Hazard ratios (calculated using Cox proportional hazards models) for overall and cause-specific premature death based on uterine fibroids confirmed by ultrasound or hysterectomy or endometriosis verified by laparoscopy and reported in biennial questionnaires.