Bupropion of no significant benefit for enhancing sexual desire in cancer survivors: Study
USA: Bupropion was not more beneficial than placebo in enhancing the Female Sexual Function Index (FSFI) desired subscale, according to a recent study led by Debra L. Barton and colleagues. On December 10, 2021, the outcomes of this study were published in the Journal of Clinical Oncology.
Since cancer therapy has a deleterious influence on female sexual function, effective remedies are required. The goal of this multisite trial was to see if two dose levels of extended-release bupropion, a dopaminergic drug, might boost sexual desire more than placebo after 9 weeks, as judged by the desire subscale of the FSFI, and to see if there were any side effects.
For this study postmenopausal women with breast or gynecologic cancer who had undergone decisive cancer therapy and had a low baseline FSFI desire score (3.3) were eligible. Women were randomly randomized to receive either 150 mg or 300 mg of extended-release bupropion once a day, or a corresponding placebo. As the major endpoint, t-tests on the FSFI desire subscale were used to determine if there was a substantially bigger change from baseline to 9 weeks between the placebo and each bupropion arm. Using a one-sided t-test, 62 patients each arm yielded 80 percent power.
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