New approach to reducing Breast Cancer Incidence and Mortality

She says these strategies may be beneficial in reducing hormone-sensitive breast cancer tumors that have a good prognosis, and they also may be beneficial in preventing tumors that are not hormone-sensitive and have a poor prognosis.

"For many years, breast cancer prevention research has primarily focused on the use of anti-estrogen medications to reduce the incidence of favorable, hormone-sensitive breast cancers, but it is critical that we reexamine and implement other risk-reducing strategies to prevent unfavorable breast cancers, known as triple-negative tumors," says Dr. Pruthi.

She encourages women and their health care providers to consider a comprehensive approach to breast cancer prevention that includes risk assessment; awareness of modifiable lifestyle factors, including low-fat dietary interventions; and use of medications that reduce the risk of dying from breast cancer.

Dr. Pruthi says her commentary was based on research conducted in two large randomized clinical trials: the Women's Health Initiative Dietary Modification trial and the Women's Health Initiative randomized trial with conjugated equine estrogen in women with prior hysterectomy. She says both clinical trials demonstrated a reduction in death from breast cancer.