GERD Increases Risk of primary acquired nasolacrimal duct obstruction among elderly, confirms study
Researchers have found in a new study published in Eye that gastroesophageal reflux disease (GERD) significantly increases the risk of primary acquired nasolacrimal duct obstruction (PANDO), especially among women and older adults. The findings show that patients who have GERD face more than twofold risk of PANDO compared to those who do not have GERD. The study was conducted by Yung-Yu Chu and fellow researchers.
This large global study was predicated on over 157 million patient records worldwide in 18 different countries, and assessed the association between GERD and PANDO. This was a retrospective cohort study with data collected worldwide from the TriNetX Global Collaborative Network. Patients diagnosed with GERD between January 2004 and November 2024 were included in the study along with non GERD controls. To validate results, patients with prior or existing lacrimal passage disorders were excluded. The primary outcome was incidence of PANDO, with follow up of up to 20 years, for each patient and for a specified duration. Lastly, we used propensity score matching to balance baseline characteristics between the patients, and Cox proportional hazards regression to assess the relative risk.
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