Abnormal immune suppression linked to poor healing of bone injury: Study
USA: Increased circulating levels of MDSCs and IL-10 (immunosuppressor cells) is associated with poor functional regeneration of traumatic bone injuries, suggests a recent study in the Proceedings of the National Academy of Sciences.
The results suggest that the early systemic immune response to trauma can be helpful in predicting the long-term effectiveness of bone healing and may inform immunotherapies development for orthopedic repair.
Severe traumatic injuries results in chronic nonunion that presents a widespread and challenging clinical problem and delayed treatment of an established nonunion is associated with variable outcomes and often prolonged patient disability. Despite this, the factors that drive successful healing and restoration of function are still not well understood. Dysregulated immune response following injury is known to be one recently identified risk factor for poor healing outcomes.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.