Lateral ankle sprains are common among active individuals and, if not managed properly, can result in recurrent sprains, chronic instability, and post-traumatic ankle osteoarthritis. Standard treatment includes physical therapy and a brief period of rest, followed by early functional rehabilitation. Autologous platelet-rich plasma, which is rich in growth factors, has demonstrated promising healing responses in acute ankle sprains.
Sumit Banerjee et al conducted a systematic review to assess the current evidence regarding the efficacy and adverse events associated with autologous PRP injection in acute ankle sprain injuries.
The authors conducted an electronic search across PubMed, Embase, Scopus, and Cochrane Library using specific keywords. Eligible studies comprised prospective or retrospective comparisons of autologous PRP injection versus control for acute ankle sprain injuries reported in English.
The key findings of the study were:
• Three randomized controlled trials and one prospective comparative study met the inclusion criteria, involving 85 ankle injuries in 84 autologous PRP injection groups and 57 ankle injuries in 56 patients in the control group.
• Autologous PRP injection provided superior short-term pain relief, functional outcomes, and an earlier return to activity and sports, as well as improved radiological outcomes compared to the control group. However, during the follow-up period, both groups exhibited comparable results in terms of Visual Analog Scale (VAS) scores and functional outcomes, with no reported adverse events.
• A meta-analysis of limited data for VAS and American Orthopaedic Foot and Ankle Society scores demonstrated comparable outcomes between the two groups.
The authors concluded – “This systematic review of four studies has shown that there is a definite improvement in pain as evaluated by VAS score and functional outcome in the short term, which is translated to the early return to activity and sports in the PRP injection group than control; however, in due course of follow-up results were equivocal for both the groups without a short- or long-term adverse event related to PRP injection. However, we need multicentric RCTs with a larger population to substantiate the result, establish the efficacy of PRP, and look for long-term outcomes.”
Further reading:
Efficacy of Autologous Platelet-Rich Plasma for the Treatment of Ankle Sprain: A Systematic Review of Literature with Limited Meta-Analysis
Sumit Banerjee et al
Indian Journal of Orthopaedics (2025) 59:910–919
https://doi.org/10.1007/s43465-025-01418-1
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