Dexamethasone with Vitamin B12 reduces postoperative pain in lumbar disc herniation patients, reveals study
A recent study published in the Journal of Orthopaedic Surgery and Research found that combining dexamethasone and vitamin B12 (VB12) through epidural injection can significantly improve early postoperative outcomes for patients undergoing percutaneous endoscopic interlaminar discectomy (PEID).
PEID is a minimally invasive procedure used to treat lumbar disc herniation (LDH). While it is generally effective, some patients experience residual pain post-surgery, impacting their recovery and overall quality of life. The study investigated whether supplementing PEID with epidural injections of dexamethasone and VB12 could reduce postoperative pain and improve recovery metrics.
This study enrolled patients who had undergone PEID for LDH and randomly divided them into 2 groups where one was the single surgery (SS) group, which only received PEID and the other was combined treatment (CT) group, which received both the surgery and an epidural injection of dexamethasone and VB12. The evaluation criteria included the Visual Analog Scale (VAS) for pain, the Japanese Orthopaedic Association (JOA) score for functional assessment, and the Oswestry Disability Index (ODI) for measuring disability. Other important metrics included the expression levels of serum inflammatory factors, adverse surgical events, postoperative hospitalization duration, and overall recovery according to the modified MacNab criteria.
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