Guselkumab drastically reduces fatigue in psoriatic arthritis patients:Study
Recent research reports have confirmed that in patients with active of psoriatic arthritis , guselkumab 100mg Q4W or Q8W led to clinically meaningful and sustained improvements in fatigue through 1 year. The findings have been published in Arthritis Research & Therapy.
Guselkumab (Janssen Biotech, Horsham, PA, USA), a high-affinity, human monoclonal antibody specific to the interleukin (IL)-23p19-subunit, is approved to treat patients with moderate-to-severe psoriasis and active PsA.It is well documented that the interleukin-23p19-subunit inhibitor guselkumab effectively treats signs and symptoms of psoriatic arthritis (PsA).With this background,a team of researchers evaluated the effect of guselkumab on fatigue.
For the study protocol, across two phase 3 trials of guselkumab (DISCOVER-1, DISCOVER-2), patients with active PsA despite standard therapy were randomized to subcutaneous injections of guselkumab 100 mg every 4 weeks (Q4W, N = 373); guselkumab 100 mg at week 0, week 4, and then Q8W (N = 375); or placebo (N = 372) through week 24, after which patients in the placebo group crossed over to guselkumab Q4W. Fatigue was measured as a secondary endpoint using the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue instrument (range 0–52, higher scores indicate less fatigue). Mediation analysis was used to adjust for indirect effects on fatigue deriving from improvement in other outcomes, including ≥20% improvement in American College of Rheumatology criteria (ACR20; prespecified), minimal disease activity (MDA; post hoc), or C-reactive protein (CRP; post hoc).
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