Inadequate anticoagulation and hyperuricemia may cause knee pain after platelet-rich plasma injection: Study
A recent study provided strong evidence that platelet-rich plasma (PRP) therapy can delay the need for total knee replacement (TKR) in patients suffering from knee osteoarthritis (OA). However, the findings highlighted the importance of the preparation process, particularly the type and amount of anticoagulant used, which appears to significantly influence treatment outcomes.
The study retrospectively analyzed data from a total of 225 patients with knee OA who received PRP treatment between June 2021 and January 2022. The primary goal was to examine the relationship between the use of different anticoagulants in PRP preparation and the level of post-treatment pain experienced by patients. Also, the study evaluated the long-term efficacy of PRP treatment and identify other factors that might affect the success of therapy.
The patients were divided into groups based on the type and amount of anticoagulant used during the preparation of PRP. The groups included the individuals treated with varying doses of 4% sodium citrate (SC) (0.6 mL, 1 mL, and 2 mL) and heparin (0.1 mL and 0.2 mL). The research assessed pain levels after treatment, as well as the presence of inflammatory markers in the joint fluid like interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and hypersensitive C-reactive protein (hs-CRP).
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.