Low-dose aspirin equally effective for VTE prevention in joint surgeries: Study

Rochester, MN: Twice-daily low-dose aspirin is equally effective as twice daily regular-dose aspirin for the prevention of venous thromboembolism (VTE) in patients with primary TJAs, finds a recent study in the Journal of Arthroplasty. The researchers found no difference in risk of mortality or gastrointestinal bleeds in the two groups.

Whether low-dose (81 mg) or regular-dose (325 mg) aspirin (ASA) is more effective for VTE chemoprophylaxis in primary total joint arthroplasties (TJAs) is not clear. To fill this knowledge gap, Mason E. Uvodich, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, and colleagues aimed to evaluate the efficacy of low-dose and regular-dose ASA for VTE chemoprophylaxis in primary total hip arthroplasties and total knee arthroplasties.

For the purpose, the researchers retrospectively identified 3512 primary TJAs (2344 total hip arthroplasties and 1168 total knee arthroplasties). In these cases ASA was used as VTE chemoprophylaxis between 2000 and 2019

Patients received ASA twice daily for 4-6 weeks after surgery with 961 (27%) receiving low-dose ASA and 2551 (73%) receiving regular-dose ASA.

The primary endpoint was 90-day incidence of symptomatic VTEs. Secondary outcomes were gastrointestinal (GI) bleeding events and mortality.