People with Intellectual Disability have higher incidence of osteoporotic fractures: Lancet

The key findings of this study were:

1. Along with 215733 matched control persons, 43176 individuals with ID were discovered and included (40.4% of them were female).

2. Females had an incidence of any fracture of 143.5 (131.8-156.3) against 120.7 (115.4-126.4)/10000 py for children and 174.2 (166.4-182.4) versus 118.2 (115.3-121.2)/10000 py for adults.

3. IRR for major osteoporotic fracture was 1.81 (1.50-2.18) for those aged 18 to 49 and 1.69 (1.53-1.87) for individuals over 50 in women.

4. For men, it was 1.56 (1.36-1.79) for ages 18 to 49 and 2.45 (2.13-2.81) for ages 50 and beyond. IRR for hip fracture was 7.79 (4.14-14.65) years old for males and 2.28 (1.91-2.71) years old for women for the same age range. It was 6.04 (4.18-8.73) for males aged 18 to 49 and 3.91 (3.17-4.82) for those aged 50 and older.

5. Comparable rates of major osteoporotic fracture and hip fracture occurred in women and men with ID at intervals of 15 and 20 years, respectively, and 30 and 40 years, respectively, sooner than at comparable intervals in the absence of ID.

6. Adults with and without ID had a markedly different fracture distribution, with hip fractures accounting for 9.9% of all fractures and 5.0% of those without.

Reference: 

Frighi, V., Smith, M., Andrews, T. M., Clifton, L., Collins, G. S., Fuller, A., Roast, J., & Holt, T. A. (2022). Incidence of fractures in people with intellectual disabilities over the life course: a retrospective matched cohort study. In eClinicalMedicine (p. 101656). Elsevier BV. https://doi.org/10.1016/j.eclinm.2022.101656