Screening for hypophosphatasia may prevent complications in Fibromyalgia
Hypophosphatasia refers to incomplete or defective bone mineralization due to ALP gene mutation, which causes low levels of ALP. The Disease has a heterogeneous presentation presenting as a chronic pain syndrome like fibromyalgia (FM). Patil Injean, in a recent study, found that the % of patients with fibromyalgia (FM) found to have consistently low alkaline phosphatase (ALP) levels was 9.3%. None of these patients had vitamin B6 levels or genetic testing, suggesting that a hypophosphatasia (HPP) diagnosis was not suspected. Given the availability of enzyme replacement therapy to prevent complications from HPP, such as fractures, it is vital to diagnose HPP. This study supported the inclusion of HPP screening as part of the initial evaluation of FM.
The co-researcher of this study Could Some Patients With Fibromyalgia Potentially Have Hypophosphatasia? A Retrospective Single-Center Study is John Tan, and the research is published in ACR Open Rheumatology.
No studies yet have investigated levels of ALP in Fibromyalgia patients. Previous research has identified adult-onset HPP in patients with a prior diagnosis of FM. Previous case reports have reported the incidence of adult-onset HPP in patients who were initially diagnosed with FM. Researchers determined whether there are any potential patients with HPP in the group of patients previously diagnosed with FM. The usage of Antiresorptive therapy can trigger atypical femur fractures in HPP patients.
Further reading:
https://acrjournals.onlinelibrary.wiley.com/doi/full/10.1002/acr2.11591
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