Tofacitinib Does not Raise risk of VTE in Rheumatoid Arthritis Patients: Study
Venous thromboembolism (VTE), which includes deep venous thrombosis (DVT) and pulmonary embolism (PE), is a common medical problem with an annual incidence of 1–2 new cases per 1,000 population. VTE has been determined to be an important identified risk of tofacitinib treatment. However, a recent study suggests that tofacitinib does not increase the risk of VTE when compared with tumour necrosis factor inhibitors (TNFIs) in patients with rheumatoid arthritis (RA). The study findings were published in the journal RHEUMATOLOGY on March 22, 2021.
Tofacitinib is a Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ulcerative colitis (UC). Recently, a link between VTE and JAK inhibitors has emerged, causing the FDA to recommend a black box label in 2019 cautioning prescribing tofacitinib for patients with a higher risk of VTE. To further evaluate this, researchers of the Brigham and Women's Hospital & Harvard Medical School, USA, conducted a study to investigate the risk of VTE with tofacitinib compared to tumour necrosis factor inhibitors (TNFIs) in patients with rheumatoid arthritis (RA).
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