Tofacitinib may benefit Psoriatic Arthritis patients as monotherapy: LANCET study
According to recent research, it has been observed that some patients with psoriatic arthritis who are stable on tofacitinib 5 mg twice daily with background methotrexate might be able to discontinue methotrexate without clinically meaningful changes in disease activity and safety, as published in the The Lancet.
Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Hence, Peter Nash and colleagues from the Griffith University, Brisbane, QLD, Australia conducted this study to evaluate the efficacy and safety of tofacitinib 5 mg twice daily monotherapy after methotrexate withdrawal.
The authors carried out an OPAL Balance study which is classified as an open-label, long-term extension study of tofacitinib in patients with psoriatic arthritis who participated in the OPAL Broaden and OPAL Beyond phase 3 studies. This 12-month, randomised, double-blind, placebo-controlled, methotrexate withdrawal substudy (50 centres, 14 countries) included patients from OPAL Balance who completed tofacitinib treatment for 24 months or more (≥3 months' stable tofacitinib 5 mg twice daily) and were receiving methotrexate (7·5–20 mg/week).
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