Using Romosozumab prior to Antiresorptive Medication tied to better BMD gains: Study
According to recent research, investigators have found that treatment with Romosozumab first produces substantial BMD gains at the total hip and lumbar spine within 1 year, and that subsequent transition to a potent antiresorptive can augment those gains, as published in the American College of Rheumatology.
Prior studies of anabolic/antiresorptive treatment sequences indicate that using teriparatide first followed by an antiresorptive results in greater bone mineral density (BMD) gains, particularly at the total hip, vs using an antiresorptive first followed by teriparatide. Romosozumab (Romo) increases bone formation while decreasing bone resorption, significantly increasing BMD and reducing fracture risk within 1 year. Therefore, "Treatment sequence is important with romosozumab," said Felicia Cosman, M.D., professor of medicine at Columbia University College of Physicians and Surgeons in New York City.
Dr. Cosman and colleagues evaluated percentage change from baseline in BMD at the total hip and lumbar spine from four trials where patients received Romo prior to an antiresorptive (Phase 3 ARCH and Phase 3 FRAME or Romo following antiresorptive therapy (Phase 3 STRUCTURE and Phase 2. Percentage change from baseline BMD was assessed by either an ANCOVA (FRAME) or repeated measures (ARCH, STRUCTURE) model adjusting for baseline covariates, or as summary statistics.
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