Vitamin D Improves Outcomes of Early Knee Osteoarthritis: Study
Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. A recent study finding suggests that early knee osteoarthritis (EOA) patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety as well as poor social participation. The study findings were published in the journal Nutrients on November 12, 2021.
The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. Therefore, researchers of Spain conducted a study to evaluate the association of serum concentrations of vitamin D with knee EOA. They further determined the association of serum concentrations of PTH with knee EOA and the relationship between vitamin D deficiency, parathyroid hormone (PTH) level, and pain intensity, disability, psychological and functional variables in patients with knee EOA.
The researchers conducted a cross-sectional study in which they included a total of 96 patients, among which 48 with EOA and 48 matched controls. The researchers evaluated serum 25(OH)D and PTH levels. They also evaluated the physical and psychological variables to establish their relationship with vitamin D levels. They used the visual analogue scale to measure the pain intensity. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire is self-administered was used to assess the OA disability. The researchers also employed the five-Time Sit to Stand test to assess functional capacity. In addition, psychological and social variables were measured to establish their relationship with vitamin D levels.
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