Respiratory Distress in the Term Newborn: IAP Guidelines

Written By :  Ayesha Sadaf
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2023-01-20 14:30 GMT   |   Update On 2023-01-20 14:30 GMT
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Respiratory distress (RD) in newborn is characterized by increased work of breathing (WOB) in the form of tachypnea, grunting, chest retractions, and often associated with reduced air entry and cyanosis.

Respiratory distress is common in the neonatal period. Incidence of RD is around 5% in term, 15% in late preterm, and >30% in infants with gestation <34 weeks.

The Indian Academy of Pediatrics (IAP) has released Standard Treatment Guidelines 2022 for Respiratory Distress in the Term Newborn. The lead author for these guidelines on Respiratory Distress in the Term Newborn is Dr. Srinivas Murki along with co-author Dr. Umamaheswari B and Dr. Rameshwor Yengkhom. The guidelines come Under the Auspices of the IAP Action Plan 2022, and the members of the IAP Standard Treatment Guidelines Committee include Chairperson Remesh Kumar R, IAP Coordinator Vineet Saxena, National Coordinators SS Kamath, Vinod H Ratageri, Member Secretaries Krishna Mohan R, Vishnu Mohan PT and Members Santanu Deb, Surender Singh Bisht, Prashant Kariya, Narmada Ashok, Pawan Kalyan.

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Following are the major recommendations of guidelines:

Assessment of Severity:

Downes and Silverman Anderson Score (SAS) on the clinical evaluation, oxygen saturation (SpO2 ) and fraction of inspired oxygen (FiO2 ) requirement, oxygen saturation index (OSI), alveolar-arterial diffusion gradient of oxygen (A-aDO2 ), oxygenation index (OI), and arterial blood gas parameters are useful in the assessment of severity of RD in a term infant. There are various clinical scoring systems for assessing the severity of RD objectively, out of which Downes scoring (Tables 1) and Silverman Anderson (Tables 2) scoring systems are widely used. Downes scoring system is used for term neonates whereas SAS score is often used in preterm neonates. A total score of 0 suggests no distress, score of 1–4 mild RD, score of 5–7 moderate RD, and score of >7 severe distress or impending respiratory failure.

TABLE 1: Downes score.

Score

Respiratory rate

Cyanosis

Air entry

Grunt

Retraction

0

<60 breaths/minute

Nil

Normal

None

Nil

1

60–80 breaths/minute

In room air

Mild decrease

Audible with stethoscope

Mild

2

>80 breaths/minute or apnea

In >40%

oxygen

Marked decrease

Audible without stethoscope

Moderate- to-severe

TABLE 2: Silverman Anderson score (SAS).

Score

Upper chest*

Lower chest#

Xiphoid retractions

Nares dilatation

Grunting

0

Synchronized

No retractions

None

None

None

1

Lag on inspiration

Just visible

Just visible

Minimal

Heard with stethoscope

2

Seesaw

Marked

Marked

Marked

Heard without stethoscope

* Part of the chest anterior to mid-axillary line.
# Part of the chest posterior to mid-axillary line.
Pulse Oximetry:
Noninvasive saturation monitoring by pulse oximetry helps in assessing the severity.
Saturation level <95% indicates the need for intervention.
Preductal saturation target for a sick newborn on respiratory support is 90–95%.
Oxygen saturation index can be calculated for any neonate on invasive respiratory support. OSI value of <7 suggests mild hypoxic respiratory failure (HRF), 7–15 moderate HRF, and >15 severe HRF.
Pulse oximetry screening is useful in early detection of critical congenital heart disease (CHD). All neonates must undergo preductal (right upper limb) and postductal (one of the lower limb) saturation check around or after 24 hours of life and saturation <95% or saturation difference between preductal and postductal of >3% is considered as screen positive and should undergo echocardiography.
Other Assessment Tools:
Calculation of various formula

Saturation index = (MAP × FiO2)/SpO2

A-aDO2 = (700 × FiO2) (PaCO2 + PaO2) or

= (760* – Water vapor pressure × FiO2) – (PaCO2/0.8#) – PaO2

PF ratio = PaO2/FiO2

Oxygenation index = (MAP × FiO2)/PaO2

*760 denotes the atmospheric pressure at sea level

#0.8 denotes respiratory quotient

(MAP: mean airway pressure; FiO2: fraction of inspired oxygen; PaO2 and PaCO2: calculated from arterial blood gas; SpO2: saturation from pulse oximeter)

Alveolar–Arterial Diffusion Gradient of Oxygen:

A-aDO2 is the difference between amount of oxygen in alveoli and the amount of oxygen dissolved in plasma (arterial oxygenation).

A-aDO2 values could reach up to 200–400 in severe RD syndrome, persistent pulmonary hypertension (PPHN) and severe meconium aspiration syndrome (MAS).

PF Ratio (PaO2 /FiO2 ):

This is one of the measures used in ventilated neonates. Ratio of <300 mm Hg indicates abnormal gas exchange.

Oxygenation Index:

This is commonly used in neonates to assess the severity and to guide on the timing of intervention.

OI value of <15 suggest mild HRF; 15–25 suggests moderate HRF; values >25 suggest severe HRF, and the need for inhaled nitric oxide (iNO) therapy.

A persistent value above 40 is an indication for extracorporeal membrane oxygenation (ECMO).

Blood Gas Analysis:

Arterial or capillary blood gas analysis helps in assessing the severity of RD and guiding the management.

Normal range of blood gas values in neonates are:

• pH 7.35–7.45, PaCO2 35–45 mm Hg, PaO2 45–80 mm Hg, bicarbonate 20–24 mEq/L, and base deficit 3–7 mEq/L.

Etiology:

Causes of RD in term neonates are depicted in Table 3.

TABLE 3: Causes of respiratory distress.

Common causes

Uncommon causes

  • Transient tachypnea of the newborn (TTN)
  • Meconium aspiration syndrome (MAS)
  • Respiratory distress syndrome (RDS)
  • Congenital pneumonia/sepsis
  • Persistent pulmonary hypertension (PPHN)
  • Perinatal asphyxia
  • Critical congenital heart disease
  • Congenital diaphragmatic hernia (CDH)
  • Air leak syndrome: Pneumothorax
  • Inborn errors of metabolism
  • Anemia/high output failure
  • Acidosis, hypoglycemia, hypothermia, and hyperthermia
  • Cardiac: Arrhythmias and cardiomyopathy
  • Upper airway anomaly: Choanal atresia, micrognathia, Pierre Robin sequence, laryngeal web, tracheal atresia, and vascular rings
  • Respiratory: Alveolar capillary dysplasia, surfactant protein deficiency, pulmonary lymphangiectasis, and pulmonary alveolar proteinosis
  • Thoracic: Chest wall deformities, skeletal dysplasia, hydrops fetalis, and phrenic nerve palsy
  • Neuromuscular: Neuromuscular disorders, cerebral malformations, maternal sedation,

and birth injury

History, onset of RD, and clinical evaluation are useful in identifying the etiology of RD in term infant (Tables 4 and 5).

TABLE 4: Etiology according to the onset of respiratory distress.

Onset

Etiology

<6 hours of life

  • Transient tachypnea of newborn (TTN)

þ Early-onset pneumonia/sepsis

þ Meconium aspiration syndrome (MAS)

þ Perinatal asphyxia

þ Congenital diaphragmatic hernia (CDH)

>6–12 hours of life

  • Sepsis

þ Pneumonia

  • Critical congenital heart disease (duct dependent systemic and pulmonary)

þ Hypothermia and hypoglycemia

þ Inborn error of metabolism

þ Congenital pulmonary airway malformation (CPAM)

TABLE 5: Etiology based on history.

History

Presentation

History of maternal diabetes

RDS, TTN, MAS, and asphyxia

History of maternal fever/PPROM/chorioamnionitis

Sepsis and pneumonia

Fetal distress/CTG abnormality

Asphyxia

Elective cesarean section without labor

TTN

Consanguinity/previous sibling death

Inborn errors of metabolism (IEM)

Antenatal scan abnormality:

  • Polyhydramnios
  • Oligohydramnios
  • Specific scan abnormality

Tracheoesophageal fistula, CDH, and CPAM Pulmonary hypoplasia

CDH, CPAM, pleural effusion/hydrops, and

congenital heart disease

(CDH: congenital diaphragmatic hernia; CPAM: congenital pulmonary airway malformation; CTG: cardiotocography; MAS: meconium aspiration syndrome; PPROM: preterm premature rupture of membrane; RDS: respiratory distress syndrome; TTN: transient tachypnea of newborn)
Diagnosis :
Chest X-ray, ultrasound lungs, and echocardiography helps in differentiating various etiology of RD in neonates apart from history and clinical examination (Table 6).

TABLE 6: Chest X-ray and ultrasound findings in various conditions.

Condition

Chest X-ray

Ultrasound lung

TTN

Sun burst appearance; fluid in minor fissure

Thickened pleural lines, B lines, double lung point

MAS

Hyperinflation with bilateral patchy lung opacities

Disappearance of A lines, scattered B lines

RDS

Reticulogranular opacities/ground glass appearance

B lines, white lungs

Pneumonia

Asymmetrical parenchymal infilterates

Nonspecific changes

Pneumothorax

Collapsed lung border with air in pleural space with mediastinal shift

Absence of sliding sign; Bar code sign

(RDS: respiratory distress syndrome; TTN: transient tachypnea of newborn; MAS: meconium aspiration syndrome)
Differential Diagnosis:
Table 7 elucidates the differences between congenital heart disease (CHD) and pulmonary disease.

TABLE 7: Differences between CHD and pulmonary disease.

Pulmonary disease

Cyanotic heart disease

Onset of respiratory distress

Since birth or within 6 hours of life

Usually after 24 hours, when the ductus arteriosus closes

History

Risk factors such as maternal fever, prolonged rupture of membranes, and meconium-stained amniotic fluid could be elicited

Family history of congenital heart disease may be seen

Antenatal scans

Could detect congenital malformations such as CDH, CPAM, tracheoesophageal fistula

Structural heart conditions could have been detected in antenatal scans

Respiratory distress

Usually moderate to severe distress associated with chest retractions

Silent tachypnea in cardiac conditions with reduced pulmonary flow; mild- to-moderate distress in conditions with increased pulmonary blood flow

Other signs

Scaphoid abdomen and hyperinflated chest in CDH; copious secretion in TEF; septic shock can be present in

pneumonia; barrel-shaped chest in MAS; labile saturations; and hypoxia during handling in PPHN

Cyanosis, murmur, signs of cardiac failure (gallop rhythm, and hepatomegaly), prominent precordial pulsations, single second heart sound, and feeble femoral pulses

Pulse oximetry screening

Occasionally positive (false positive in PPHN and certain respiratory conditions)

Positive with greater accuracy

Arterial blood gas

Hypoxia (PaO2 low) Hypercapnia (PaCO2 high)

Hypoxia (PaO2 low) Hypocarbia or normocarbia (PaCO2 normal or low)

Hyperoxia test*

PaO2 > 150 mm Hg

PaO2 < 150 mm Hg

Chest X-ray

No cardiomegaly

Patchy consolidation in pneumonia; bilateral patchy infiltrates with hyperinflation-MAS; prominent bronchovascular marking and fluid in minor fissure TTN; normal lungs in PPHN; ground glass appearance in RDS

Egg on side appearance in TGA; normal or small heart with pulmonary edema in obstructive TAPVC; box- shaped heart in Ebstein anomaly

Echocardiography

Structurally normal heart; could show features of PPHN

Confirms the diagnosis

* Limited value with advent of echocardiography; also it carries risk of oxygen toxicity. (CDH: congenital diaphragmatic hernia; CHD: congenital heart disease; CPAM: congenital pulmonary airway malformation; MAS: meconium aspiration syndrome; PPHN: persistent pulmonary hypertension; RDS: respiratory distress syndrome; TAPVC: total anomalous pulmonary venous connection; TEF: tracheoesophageal fistula; TGA: transposition of the great arteries; TTN: transient tachypnea of the newborn)
Other Differentials:
Metabolic Acidosis :
Metabolic acidosis causes deep and high rate of breathing as a compensatory mechanism to wash out the partial pressure of carbon dioxide (pCO2 ). Air entry would remain good and characterized by absence of associated finding such as grunting or cyanosis. SpO2 is normal and above 95%.
Anemia:
Anemia results in tachypnea as a part of high output cardiac failure. History of antepartum hemorrhage or Rh incompatibility along with clinical examination showing pallor should rise the suspicion of anemia and appropriate evaluation should be carried out.
Treatment:
  • General Therapy
TABC: Maintain thermoneutral zone, clear the airway, and ensuring adequate breathing and circulation. Maintain skin temperature between 36°C and 37°C. RDS and PPHN are aggravated by hypothermia.
Continuous clinical and pulse oximeter monitoring to be done to determine the requirement for respiratory support (including escalation and de-escalation of support and type).
Maintain euglycemia, normal fluid and electrolyte balance. Ensure a minimum glucose infusion rate of about 4 mg/kg/min for adequate glucose homeostasis. In at risk newborns, 6–8 mL/kg/day of calcium gluconate to be added to the fluid. Enteral feeding should be started as soon as the infant is clinically stable and escalated to full feeds.
Maintenance of adequate and age-appropriate hematocrit.
Antibiotics are usually not required. Decision to start antibiotics would depend on the clinical situation, but the threshold should be low.
Warm, humidified oxygen should be given with soft nasal cannula preferably with an FiO2 meter and pulse oximeter monitoring to titrate the concentration of oxygen needed. Avoid using hood oxygen. When on any respiratory support maintain SpO2 between 90 and 95%.
When low flow nasal oxygen (<2 L/min) with nasal cannula fail to maintain target oxygen saturation (just above 94%) and PaO2 of 50–80 mm Hg, heated humidified high-flow nasal cannula (HHHFNC) may be tried first. Begin with a flow of 4–6 L/ min and increase @ 0.5–1 L/min as required [suggested by increasing respiratory rate (RR), WOB, and FiO2 requirement) till a maximum of 8 L/min.
If target saturation (90–95%) are not maintained or in those with increased WOB, noninvasive respiratory support by either continuous positive airway pressure (CPAP) or nasal intermittent positive pressure ventilation (NIPPV) should be started. Indications for starting CPAP are a Downes or Silverman score of ≥5 or an FiO2 requirement of >0.3 to maintain an acceptable saturation on pulse oximeter. CPAP is started with a positive end-expiratory pressure (PEEP) of 5 cmH2 O, FiO2 of 0.3 and titrated to maximum of 8 cmH2 O and 0.6 FiO2 , respectively. NIPPV is started with initial settings of PEEP of 5 cmH2 O, peak inspiratory pressure (PIP) of 14 cmH2 O, rate of 30 bpm, Ti of 0.50 second, FiO2 of 0.3 and titrated to a maximum PEEP of 8 cmH2 O, PIP 25 cmH2 O, rate 50 bpm, Ti 0.5 second and FiO2 0.6, respectively.
When noninvasive ventilation (NIV) fails, intubate and switch to invasive mechanical ventilation (IMV). Ventilation mode should depend on infant's clinical condition, type of ventilator, and clinician's preference. Patient triggered ventilation with volume guarantee (4 mL/kg) is considered the best. For best outcomes this should be given to babies in impending respiratory failure or failed CPAP rather than in complete respiratory failure. Indications for IMV are FiO2 requirement >0.6 to maintain target SpO2 , respiratory acidosis (PaCO2 > 60 mm Hg), pH <7.2, or recurrent apnea. CPAP is said to have failed when the FiO2 requirement is >0.6 or the CPAP required to maintain oxygenation exceeds 8 cmH2 O. Respiratory failure is defined a PaCO2 > 60 mm Hg or PaO2 < 50 mm Hg, or saturation < 85% in 100% O2 with or without a pH of <7.25. If conventional IMV fails, especially in MAS with PPHN, consider switching to high-frequency oscillatory ventilation (HFOV), if available. Indications for HFOV are requirement of PIP > 28 cmH2 O, FiO2 > 0.6, respiratory acidosis with pH < 7.2 on conventional IMV.
ECMO: ECMO is a life-saving therapy in neonates with severe hypoxic failure not responding to conventional therapy and acts as a bridge to recovery.
Specific Therapy :
  • Surfactants
Surfactant is the drug of choice in babies with RDS/hyaline membrane disease (HMD) (term born babies >37 weeks account for 7.8% of total RDS cases in newborns, more common among early term infants of 37–38 weeks and in infants of diabetic mother).
It is given as early rescue therapy within the first few hours of birth when newborn is on CPAP or NIV or MV and has FiO2 requirement of >0.40 and chest X-ray is suggestive of RDS.
Natural surfactants are preferred. Poractant alpha at an initial dose of 200 mg/ kg or beractant at a dose of 100 mg/kg administered by intubation-surfactantextubation (INSURE), less invasive surfactant administration (LISA), or minimally invasive surfactant therapy (MIST) methods of surfactant administration.
Surfactants are also beneficial in MAS and/or PPHN management.
  • Antibiotics
Antibiotics should be started early in case of congenital pneumonia after collecting blood for culture and sensitivity.
Usually, unit-specific first-line antibiotics are started and adjusted later as per culture and sensitivity report. In certain situations, MAS and RDS may mimic pneumonia. In such situations, antibiotics are started and can be stopped early when clinical and laboratory parameters points toward alternative diagnoses.
  • Inotropes
Ensure adequate perfusion of organs with fluid boluses [0.9% normal saline (NS) 10 mL/kg over 20–30 minutes] and then add inotropes, if required.
Choice of inotropes, if needed, depends on etiology and evaluation of circulation, blood pressures (systolic/diastolic/MAP) assisted by functional echocardiography. Dobutamine is preferred in conditions associated with left ventricular (LV) dysfunction for its inotropic action. Milrinone has inotropic and lusitropic actions and also is a pulmonary vasodilator, so preferred in PPHN. Low-dose epinephrine has inotropic effects. Vasopressors such as dopamine, vasopressin, epinephrine (high dose), or norepinephrine are used to maintain normal blood pressure.
  • Pulmonary Vasodilators
In case of PPHN, after supportive care and lung recruitment strategies such as ventilation/surfactant, selective pulmonary vasodilator, and iNO are used when OI is >15–20. If iNO is not available or is ineffective, alternative nonselective pulmonary vasodilators, sildenafil [phosphodiesterase-5 (PDE5) inhibitor] or bosentan (endothelin-1 agonist) may be tried with an aim to reduce pulmonary pressure and improve oxygenation.
Source:Indian Academy of Pediatric Guidelines

 (A-aDO2 : alveolar-arterial diffusion gradient of oxygen; CPAP: continuous positive airway pressure; CXR: chest X-ray; FiO2 : fraction of inspired oxygen; HFNC: high-flow nasal cannula; NIV: noninvasive ventilation; OI: oxygenation index; PCV: packed cell volume; RD: respiratory distress; SpO2 : oxygen saturation; WOB: work of breathing)

Reference:
  • Cloherty JP, Eichenwald EC, Hansen AR, Stark AR. Manual of Neonatal Care, 7th edition. Netherlands: Wolters Kluwer; 2012.
  • Edwards MO, Kotecha SJ, Kotecha S. Respiratory distress of the term newborn infant. Paediatr Respir Rev. 2013;14:29-37.
  • Mathai SS, Raju U, Kanitkar M. Management of respiratory distress in the newborn. Med J Armed Forces India. 2007;63(3):269-72.
  • Pramanik AK, Rangaswamy N, Gates T. Neonatal respiratory distress: a practical approach to its diagnosis and management. Pediatr Clin North Am. 2015;62(2):453-69.
  • Reuter S, Moser C, Baack M. Respiratory distress in the newborn. Pediatr Rev. 2014;35;417-28.
  • Taeusch HW, Ballard RA, Avery ME, Gleason CA. Avery's Diseases of the Newborn, 10th edition. Amsterdam, Netherlands: Elsevier; 2018.

The guidelines can be accessed on the official site of IAP: https://iapindia.org/standard-treatment-guidelines/


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Article Source : Indian Academy of Pediatric, IAP Guidelines

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