Asthma can be prevented in kids by avoiding cow's milk formula at birth: JAMA

Researchers conducted a study to evaluate whether asthma or recurrent wheeze among children were changed by avoiding supplementing breastfeeding (BF) with cow's milk formula (CMF) in the first 3 days of life.

They conducted a randomized, unmasked, clinical trial was at one university hospital in Japan beginning October 2013 with follow-up examinations occurring until January 2020. A total of 312 newborns at risk for atopy were randomized and assigned to either breastfeeding (BF) with or without amino acid–based elemental formula (EF) or BF with cow's milk formula (CMF) ,with follow-up examinations for participants showing signs of atopy conducted at 24 months. Follow-up examinations ran through January 2020.

The investigators randomly assigned newborns Immediately after birth in (1:1 ratio) to either breastfeeding with or without amino acid–based elemental formula for at least the first 3 days of life (no CMF group) or breastfeeding supplemented with CMF (-5 mL/d) from the first day of life to 5 months of age (CMF group).

Asthma or recurrent wheeze diagnosed by the pediatric allergy specialists of this trial; subgroups were stratified by serum levels of 25-hydroxyvitamin D and IgE.

Of 312 infants (156 [50.0%] randomized to the no CMF group), 302 (96.8%) were followed up at their second birthday: 77 of 151 (51.0%) in the no CMF group and 81 of 151 (53.6%) in the cow's milk formula group underwent extended follow-up because of having atopic conditions.

Asthma or recurrent wheeze developed in 15 (9.9%) of the children in the no cow's milk formula group, significantly less than the children in the cow's milk formula group (27 [17.9%]; risk difference, −0.079; 95% CI, −0.157 to −0.002). In participants with vitamin D levels above the median at 5 months of age, asthma or recurrent wheeze developled in 5 (6.4%) children in the no CMF group, significantly less than in the children in the CMF group (17 [24.6%]; risk difference, −0.182; 95% CI, −0.298 to −0.067; P for interaction = .04). In thevhighest quartile group of total IgE at age 24 months, asthma or recurrent wheeze developed in 2 children (5.3%) in the no CMF group, significantly less than the children in the cow's milk formula group (14[43.8%]; risk difference, −0.385; 95% CI, −0.571 to −0.199; P for interaction = .004).

The researchers concluded that the findings of this study suggest that avoiding cow's milk formula supplementation in the first 3 days of life has the potential to reduce the risk of asthma or recurrent wheeze in young children, especially among those with high vitamin D or high IgE levels.

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