Hyponatremia Signals Severity in Pediatric Urinary Tract Infections: Study

Key Findings

The study involved data from 344 pediatric patients:

• Hyponatremia Prevalence: Hyponatremia was found in 99 patients (28.8%), while normal serum sodium levels were found in 245 (71.2%) patients.

• Association with APN: The hyponatremia group had a higher frequency of APN and renal abnormalities detected on ultrasound.

• CRP Levels: Higher levels of CRP were observed in the hyponatremia group. A significant association was also noted in multivariable analysis (OR: 1.00; 95% CI: 1.00–1.01, p = 0.0417).

• Serum Glucose: Hyperglycemia also has been associated with hyponatremia (OR: 1.01; 95% CI: 1.00–1.03, p = 0.0365).

• Final Diagnosis APN: Hyponatremia was associated with markers of severe disease. No significant direct correlation was seen between the final diagnosis of APN.

Hyponatremia might provide useful biomarkers for significant diseases of hospitalized pediatric UTI. However, the present research shows that although hyponatremia has relationships with systemic inflammation and renal findings, its predictive ability is limited for APN diagnosis. These findings stress the need for further study on the mechanisms and clinical utility of hyponatremia as a predictor of disease severity.

Reference: