Hypoxia tied to necrotizing enterocolitis in near term infants with CHD: Study
Researcher have recently found a hypoxic/ischemic pathophysiology of necrotizing enterocolitis in near term CHD infants, with lower Apgar scores, more respiratory support in the delivery room and a tendency towards a lower diastolic blood pressure and pH in CHD infants who develop Necrotizing enterocolitis.
This study is published in the Journal of BMC Pediatrics.
Necrotizing enterocolitis (NEC) is a devastating disease that is relatively frequently diagnosed in term infants with congenital heart disease (CHD), compared with term infants without CHD, in whom Necrotizing enterocolitis is rare. The exact pathogenesis of NEC in term infants with CHD is unknown, but it is hypothesized that ischemia of the intestines plays a pivotal role.
Therefore, Martin van der Heide and colleagues from the Division of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, The Netherlands carried out the present study to explore whether (near) term CHD infants, who develop NEC, exhibit more clinical signs of hypoxia/ischemia and low body perfusion directly after birth and during the first 48 hours after admission to the neonatal intensive care unit, when compared with (near) term CHD infants who did not develop NEC.
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