Indirect airway hyperresponsiveness test may help ascertain correct ICS dose for better asthma control in kids
In a recent study, Janusz Ciolkowski and team found that indirect airway hyperresponsiveness (AHR) test using hypertonic saline in determining the appropriate dose of inhaled corticosteroids (ICS) increased asthma control in children. The findings were published in Pediatric Pulmonology.
The study involved 104 children aged 7 to 15 years with mild to moderate atopic asthma. These patients were closely monitored for asthma control and treatment over a period of one year. They were randomly divided into two groups: a symptom-only monitored group and a group where therapy adjustments were made based on both symptoms and the severity of AHR. Throughout the study, various parameters such as spirometry, exhaled nitric oxide, and blood eosinophils (BEos) were assessed every three months.
The results revealed a notable reduction in the number of mild exacerbations in the AHR group compared to the symptom-only group. The AHR group experienced 44 mild exacerbations, while the symptom-only group had 85 (absolute rate per patient: 0.83 vs. 1.67; relative rate: 0.49, 95% confidence interval: 0.346–0.717; p < 0.001). However, no significant differences were observed in the mean changes from baseline in clinical, inflammatory, and lung function parameters between the two groups.
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