Nitrofurantoin and cranberry products could decrease risk of UTI episodes in pediatric patients: Study

The prevention of recurrent urinary tract infections (UTIs) in children has long been a complex challenge for the medical community. A recent research published in the Pediatrics Journal found that specific prophylactic measures, including the use of nitrofurantoin and cranberry products, may offer significant benefits in reducing symptomatic UTI episodes in pediatric patients.

The systematic review analyzed data from major electronic databases including PubMed/Medline, Scopus, and the Cochrane Library up to November 26, 2023. This review and meta-analysis of 23 randomized controlled trials encompassed a total of 3,335 participants to identify the most effective options for preventing recurrent UTIs and minimizing future complications such as kidney scarring. The primary metric was the incidence of symptomatic UTI in children during prophylactic treatment. Mean differences and standard deviations were used to evaluate continuous outcomes, while odds ratios were calculated for dichotomous outcomes.

The analysis revealed that both cranberry products and nitrofurantoin significantly reduced the odds of symptomatic UTI episodes when compared to control groups and alternative prophylactic treatments.

• Cranberry Products: These natural supplements were found to effectively lower the recurrence rate of symptomatic UTIs during the study period when compared to placebo or no treatment.
• Nitrofurantoin: This antibiotic emerged as the most effective intervention by outperforming other options such as trimethoprim-sulfamethoxazole and trimethoprim alone in reducing the incidence of UTIs.

The findings of this meta-analysis suggest that nitrofurantoin could be considered the preferred option for reducing symptomatic UTI recurrences in children. However, the absence of kidney scarring prevention points to a significant gap in current treatment approaches. Future randomized controlled trials should focus on exploring nonantibiotic prophylaxis methods and their potential benefits for pediatric patients at risk of both recurrent UTIs and kidney damage.

With these results, clinicians may have more clarity in selecting effective treatment plans for children prone to UTIs. Meanwhile, the parents and caregivers are advised to discuss these findings with medical professionals to understand the best approach for needs of their child. Overall, the findings of this comprehensive review opens up to a better understanding of how to manage recurrent UTIs in children and emphasizes the importance of continued research into holistic and targeted prevention strategies.

Reference:

Gkiourtzis, N., Stoimeni, A., Glava, A., Chantavaridou, S., Michou, P., Cheirakis, K., Lalayiannis, A. D., Hulton, S. A., & Tramma, D. (2024). Prophylaxis Options in Children With a History of Recurrent Urinary Tract Infections: A Systematic Review. In Pediatrics. American Academy of Pediatrics (AAP). https://doi.org/10.1542/peds.2024-066758