Adjunctive cariprazine reduces symptoms in adult patients with major depressive disorder
A new study by Gary Sachs and team showed that adults with major depressive disorder and poor response to antidepressants alone were treated with adjunctive cariprazine at a dose of 1.5 mg/day, which showed effectiveness in lowering depressed symptoms. The findings of this study were published in The American journal of Psychiatry.
The goal of this study was to determine whether cariprazine, a partial agonist of the dopamine D3/D2 and serotonin 5-HT1A receptors that prefers dopamine D3, is effective as an adjunctive treatment for people with major depressive disorder who have not responded to at least one antidepressant monotherapy.
Adults with severe depressive illness with poor response to antidepressants alone were randomized in this double-blind, placebo-controlled research in a 1:1:1 ratio to placebo, cariprazine at 1.5 mg/day, or cariprazine at 3.0 mg/day. The Montgomery-Sberg Depression Rating Scale total score change from baseline to week six was the main result (MADRS). In the modified intent-to-treat (mITT) population, least-squares mean differences were calculated using a mixed-effects model for repeated measurements with multiple comparisons correction.
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