Documented Chronic stress tied to greater risk of cognition impairment and Alzheimer's disease
Dementia is affecting more than 55 million people worldwide. Alzheimer's disease (AD) constitutes more than half of all dementia. Within five years, one-third of patients with mild cognitive impairment (MCI) develop AD.
Age is a significant risk factor for dementia. A recent study published in Alzheimer's Research & Therapy demonstrated Diagnosis of depression to be associated with an approximately threefold increased risk for later MCI and almost twofold increased risk for later AD. The risk increased further if the patients also experienced chronic stress, as indicated by a recorded diagnosis of SED. Chronic stress and depression may be independent risk factors for dementia, and together, they may have an additive effect on the risk for later dementia.
It is already known that Chronic stress and depression are potential risk factors for MCI and dementia, including Alzheimer's disease. This cohort study included 1 362 548 people with records in the Region Stockholm administrative healthcare database (VAL).
Exposure was a recorded ICD-10 diagnosis of chronic stress, depression, or both, recorded in 2012 or 2013. Alzheimer's disease diagnosis, dementia, or MCI recorded from 2014 through 2022 was the outcome. Odds ratios with 99% confidence intervals (CI) adjusted for age, sex, neighbourhood socioeconomic status, diabetes, and cardiovascular disorders were calculated.
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