History of Hormonal Contraception Use Linked to Higher Risk of Postpartum Depression: JAMA
Denmark: A new study published in JAMA: Psychiatry suggests that women who have a history of depression associated with hormonal contraception (HC) use may be at a higher risk of developing postpartum depression (PPD).
Hormonal sensitivity in women is linked to depression during specific reproductive phases, but little evidence exists for across-the-lifespan linkages.
The cohort study analyzed the Danish health registry from 1995-2017, studying 269,354 women who gave birth between 1996-2017. Researchers calculated odds ratios for postpartum depression (PPD) based on prior depression associated with or without hormonal contraception (HC) use, defined by a hospital diagnosis or antidepressant prescription.
The study concluded with the following key takeaways:
1. Of 188,648 first-time mothers studied, 3.0% had a history of depression associated with HC use, and 9.8% had a history of depression not associated with HC use.
2. Women with a history of depression associated with HC use had a higher risk of postpartum depression (PPD) compared to those with prior non-HC-associated depression.
3. The crude odds ratio for PPD in women with HC-associated depression was 1.42, and the adjusted odds ratio was 1.35.
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