Psilocybin plus mindfulness shows promise for healthcare worker depression: Study

"Depression and burnout have long been serious problems for healthcare workers. When the pandemic only worsened these effects, we felt it was crucial to try something different to understand how we can help this group of individuals who are dedicated to helping others."

Benjamin Lewis, MD Associate professor of psychiatry at University of Utah

The study, which originally appeared in PLOS Medicine, included 25 healthcare workers who worked directly with COVID patients and were battling both depression and burnout. A select group of healthcare workers were administered a single dose of psilocybin in a controlled clinical setting along with 8 weeks of mindfulness training while the other half completed the mindfulness training alone.

For those that were treated with the combination therapy, the group’s depression scores dropped by more than twice as much as the meditation-only group in addition to feeling less emotionally exhausted and more connected to themselves and others.

Nearly half (46%) of healthcare workers who received psilocybin alongside mindfulness techniques were free of depression at two weeks, compared to just 8% who only learned mindfulness practices.

Most psilocybin studies are expensive and hard to scale up as they use two therapists per patient with individual sessions. This study delivered treatment in groups instead, creating an easier path towards scaling and a more accessible option for healthcare workers looking for relief.

Reference:

Benjamin R. Lewis, John Hendrick, Kevin Byrne, Madeleine Odette, Chaorong Wu, Eric L. Garland, Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial, PLOS Medicine, https://doi.org/10.1371/journal.pmed.1004519