Rheumatoid arthritis patients more prone to depression, claims JAMA study
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by systemic inflammation. This condition may require lifelong treatment due to its chronic nature, which results in numerous comorbidities. Depression is one of the most common comorbidities in RA patients, with estimates of prevalence ranging from 14% to 48%, which is significantly higher than in the...
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by systemic inflammation. This condition may require lifelong treatment due to its chronic nature, which results in numerous comorbidities. Depression is one of the most common comorbidities in RA patients, with estimates of prevalence ranging from 14% to 48%, which is significantly higher than in the general population.
- The study population included 71 % females.
- A total of 27 063 participants, 20 641 controls and 6422 with RA developed depression.
- RA patients had a 1.66-fold higher risk of depression than controls with an adjusted hazard ratio [aHR] of 1.66.
- The SPRA and the SNRA group were associated with an increased depression risk with aHR of 1.64 and 1.73, respectively.
- RA patients who used biologic or targeted synthetic DMARDs with aHR, 1.33, had a lower depression risk compared with those who were not exposed to these medicines. The aHR was 1.69
- SPRA and SNRA were associated with a significantly higher risk of depression. This highlights the importance of early screening and intervention for mental health in RA patients.
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