Asthma Tied to Higher Risk of Heart Valve Disease, BMJ Study Finds
Written By : Medha Baranwal
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2025-08-25 15:00 GMT | Update On 2025-08-25 15:01 GMT
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China: A large-scale prospective cohort study published in Heart, a BMJ journal, has revealed that asthma may raise the risk of developing degenerative valvular heart diseases (VHD), including conditions affecting the aortic, mitral, and pulmonary valves. The research was conducted by Dr. Zuoxiang Wang and colleagues from the Department of Cardiology at the Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.
Asthma, a chronic respiratory condition marked by airway inflammation, has previously been associated with various cardiovascular disorders. However, its link to degenerative VHD remained unclear. This study aimed to address that gap by exploring whether individuals with asthma have a higher likelihood of developing these valve-related conditions.
The investigation analyzed data from 483,735 participants in the UK Biobank, all of whom were free of VHD at the outset. The median age was 56.5 years, and 45.2% were men. Asthma status was self-reported at enrollment, while cases of VHD were identified through hospital records and mortality databases using ICD-10 codes. Researchers applied Cox proportional hazards models to estimate hazard ratios (HRs) for different VHD subtypes, adjusting for multiple demographic, lifestyle, and clinical factors. Additional analyses considered asthma medication use, disease duration, and competing health risks.
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