Can hyperinsulinemia or insulin resistance lead to snoring? Study sheds light

China: Hyperinsulinemia or insulin resistance may be the reason for common snoring, a recent study in the European Journal of Clinical Investigation has suggested. The study found that people who snore may be subjected to higher glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), 2h-glucose post-challenge (2hGlu), and fasting insulin (FINS). 

Previous studies have shown snoring and impaired glucose metabolism to be common manifestations and an association between the two. Yuan Zhang, Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China, and colleagues, therefore, aimed to estimate the causal associations between snoring and glycemic traits. 

For this purpose, the researchers compared the weighted mean differences (WMD) for fasting insulin, fasting blood glucose, glycosylated hemoglobin, and 2h-glucose post-challenge levels between snorers and non-snorers by meta-analysis. Summary statistics were then obtained from published GWAS of snoring and glycemic traits to perform bidirectional two-sample MR. 

The inverse variance weighting (IVW) method was applied as major estimate while MR Egger, Weighted median and MR-Robust Adjusted Profile Score (RAPS) played a subsidiary role.