CPAP fails to reverse metabolic syndrome in most patients of sleep apnea: study
According to a recent study published in Chest, in most patients with obstructive sleep apnea, CPAP is not able to reverse metabolic syndrome.
Obstructive sleep apnea occurs when the muscles in your throat that support soft tissues such as the tongue and soft palate temporarily relax. When these muscles relax, your airway narrows or closes and breathing is momentarily interrupted.
Obstructive sleep apnea is associated with metabolic syndrome (MS), but it is unclear whether treatment of obstructive sleep apnea with CPAP can reverse the metabolic syndrome.
The TREATOSA-MS trial was a randomized, placebo-controlled trial in which adult patients with a recent diagnosis of metabolic syndrome and moderate or severe OSA (apnea-hypopnea index [AHI], ≥ 15 events/hour) were enrolled for administration of therapeutic CPAP or nasal dilator. strips for 6 months (placebo group). We measured anthropometric variables, blood pressure, glucose, and lipid profile before and after each intervention. To check for potency-related mechanisms and outcomes, they also measured biomarkers of adiposity (leptin and adiponectin), body composition, food intake, physical activity, subcutaneous and abdominal fat (visceral and hepatic fat), and endothelial function.
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