Dupilumab improves clinical outcomes in patients having chronic rhinosinusitis with nasal polyps
USA: A recent study published in Allergy & Asthma Proceedings on the efficacy of the human monoclonal antibody Dupilumab in patients with chronic rhinosinusitis with nasal polyps with and without allergic rhinitis (AR).
Anju T Peters, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, and colleagues found that dupilumab showed significant improvements in both clinical endpoints and symptom scores versus placebo in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). The improvement was seen regardless of comorbid AR status, a common subgroup of patients often associated with poorer CRSwNP outcomes.
Dupilumab is a fully human monoclonal antibody which blocks the shared receptor component for interleukin-4 and interleukin-13, key and central drivers of type 2 inflammation.
Chronic rhinosinusitis with nasal polyps is a predominant type 2 inflammatory disease, which often coexists with allergic rhinitis. Anju T Peters, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, and colleagues aimed to investigate the safety and efficacy of dupilumab in patients with severe CRSwNP with or without coexisting AR in the pooled phase III SINUS-24/SINUS-52 studies.
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