FlowTriever System benefits pulmonary embolism patients both clinically and functionally

The FlowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH) is a single-arm study for evaluating the safety and effectiveness of the FlowTriever System among a large and geographically diverse population with acute PE.

This report focuses on the longer-term outcomes, including late all-cause mortality, RV remodelling, residual symptoms, functional status, and PE-specific QoL through a 6-month follow-up after treatment with the FlowTriever System.

The study results could be summarised as follows:

• Seven hundred ninety-nine patients were enrolled.
• The study was completed by 75% of patients with a mean follow-up of 204 ± 46 days.
• Demographic characteristics were 54.1% men, a mean age of 61.2 years, 77.1% intermediate-high-risk PE, and 8.0% high-risk PE.
• At study completion, All-cause mortality was 4.6%.
• There was an increase in patients' proportion with normal echocardiographic RV function from 15.1% (baseline) to 95.1% (6 months).
• At six months, the MMRCD score improved from 3.0 (baseline) to 0.0.
• There was an increase in 6-minute walk test distances from 180 m at 48 hours to 398 m at six months.
• Median PE QoL total scores at 30 days and six months were 9.38 and 4.85, respectively.
• The Prevalence of site-reported chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease was 1.0 % and 1.9%, respectively.

They explained saying Mechanical thrombectomy provides rapid hemodynamic improvements following PE, but there is uncertainty on long-term benefits. We reported All-cause mortality as 4.6% and infrequent long-term pulmonary embolism sequelae. There was an improvement, clinically and functionally, at six months intervals.

In the study, a researcher reported low 6-month all-cause mortality, chronic thromboembolic pulmonary hypertension, and chronic thromboembolic disease after thrombectomy with the FlowTriever system.

Further reading:

https://www.jscai.org/article/S2772-9303(23)00443-X/fulltext#%20