Intravenous methylprednisolone reduces hospital stay for children with Multisystem Inflammatory Syndrome

In the ongoing battle against the multifaceted impacts of COVID-19, the RECOVERY trial examined treatment approaches for Pediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), shedding light on effective interventions and their outcomes in children. This study was published in the journal The Lancet: Child and Adolescent Health by Faust SN and colleagues.
PIMS-TS, also known as Multisystem Inflammatory Syndrome in Children (MIS-C), emerged as a concerning condition associated with COVID-19 in pediatric patients. This study focused on evaluating the effects of intravenous immunoglobulin, corticosteroids, tocilizumab, and anakinra compared with usual care on the duration of hospital stay for children with PIMS-TS.
Conducted across 51 UK hospitals, this randomized, controlled, open-label trial enrolled 237 children under 18 with PIMS-TS. The trial included two randomizations, the first assessing the impact of intravenous immunoglobulin or methylprednisolone compared with usual care, and the second evaluating tocilizumab or anakinra for inflammation refractory to initial treatment. The primary outcome measured was the duration of hospital stay.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.