Low-Dose Morphine Not Helpful for COPD Patients With Chronic Dyspnea: JAMA
Low-Dose Morphine Not Helpful for COPD Patients With Chronic Dyspnea suggests a recent study published in the JAMA.
Among the 160 people randomized, 156 were included in the primary analyses and 138 (88%) completed treatment at week 1.
The change in the intensity of worst breathlessness at week 1 was not significantly different between the 8 mg/d of morphine group and the placebo group or between the 16 mg/d of morphine group and the placebo group
At week 3, the secondary outcome of change in mean daily step count was not significantly different between the 8 mg/d of morphine group and the placebo group between the 16 mg/d of morphine group and the placebo group, between the 24 mg/d of morphine group and the placebo group or between the 32 mg/d of morphine group and the placebo group
Ekström M, et al "Effect of regular, low-dose, extended-release morphine on chronic breathlessness in chronic obstructive pulmonary disease: the BEAMS randomized clinical trial" JAMA 2022; DOI: 10.1001/jama.2022.20206.
Low-Dose, Morphine, Helpful, COPD,Patients, Chronic Dyspnea, Ekström M, JAMA
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