Shorter weekly regimen of rifapentine-isoniazid effective option for TB prevention in HIV: Study

South Africa: People with HIV infection assigned with a shorter weekly course of rifapentine-isoniazid therapy for preventing tuberculosis disease showed a higher treatment completion than those taking a longer daily course, show findings from the WHIP3TB trial. A second treatment round conferred no additional protection from developing tuberculosis disease in high-transmission areas. The study appeared in Annals of Internal Medicine.

Tuberculosis preventive therapy is effective in people with HIV, but its durability is uncertain. Researchers from the Aurum Institute, Houghton, South Africa in the WHIP3TB trial (Weekly High Dose Isoniazid and rifapentine [P] Periodic Prophylaxis for TB trial) hypothesized that, among persons with HIV receiving antiretroviral therapy, treatment completion of weekly rifapentine and isoniazid for 3 months would be superior to 6 months of daily isoniazid, and that annual weekly rifapentine and isoniazid for 3 months would be more effective than a single round.