Triple drug inhaler may effectively reduce COPD exacerbations
Daily use of triple-drug FF/UMEC/VI inhaler led to significant reductions in moderate/severe COPD exacerbations, hospitalizations and death.;
US: Chronic obstructive pulmonary disease which includes chronic bronchitis and emphysema is a long-term lung disease that causes difficulty breathing. It is the third leading cause of death although it is preventable and treatable. Most of the people die due to exacerbations of COPD.
In order to reduce this mortality, Dr Lipson from Perelman School of Medicine, University of Pennsylvania and his colleagues conducted an IMPACT study which showed once-daily treatment of patients with chronic obstructive pulmonary disease (COPD) with an inhaler combining fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) reduced all-cause mortality by 42 per cent. This study is published in the American Journal Of Respiratory and Critical Care Medicine.
Fluticasone furoate is an inhaled corticosteroid, while umeclidinium is a long-acting muscarinic antagonist (a type of bronchodilator) and vilanterol is a long-acting ß2 agonist (another type of bronchodilator).
More than 10,000 IMPACT participants with COPD who were at risk for severe exacerbations (flare-ups) were randomized to be in one of three groups: those receiving once-daily inhalations of FF/UMEC/VI, FF/VI or UMEC/VI combinations. IMPACT participants were followed for one year. The study focused on patients with a history of exacerbations of their COPD.
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