Clinical and Scientific Rationale for Use of Probiotics as Adjuvant in COVID-19
Written By : Hina Zahid
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2020-11-25 07:15 GMT | Update On 2021-02-04 08:27 GMT
Advertisement
SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) - responsible for COVID- 19 (coronavirus disease 2019) infections, has clinically affected more than 12.3 million people across 215 countries. (1) There has been continuously emerging evidence bringing out the association of gut dysbiosis and the possible need for interventions to correct the same for the management of COVID-19 infections.
COVID-19 & Gut Dysbiosis
While the clinical features of COVID-19 are associated with acute respiratory restrictions, cough, sore throat, and fever, followed by multi-organ failure and often secondary infections. (2) , it has been reported that there is a strong correlation between the progression of the disease and the composition of gut microbiota. Some patients with COVID-19 have manifested intestinal microbial dysbiosis, with a decrease in cell numbers of Lactobacillus and Bifidobacterium (3)
The above article has been published by Medical Dialogues under the MD Brand Connect Initiative. For more details on probiotics, CLICK HERE
References
Adapted from
1 Worldometer, 2020, Coronavirus, https://www.worldometers.info/coronavirus/?utm_campaign=homeADemocracynow(2020)%20dvegas1?
2 Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan. China: a descriptive study. Lancet 395, 507–513. doi: 10.1016/S0140-6736(20)30211-7
3 Xu, K., Cai, H., Shen, Y., Ni, Q., Chen, Y., Hu, S., et al. (2020). Management of corona virus disease-19 (COVID-19): the zhejiang experience . Zhejiang Da Xue Xue Bao Yi Xue Ban. 21:49.
4 Tiwari SK, Dicks LMT, Popov IV, Karaseva A, Ermakov AM, Suvorov A, Tagg JR, Weeks R and Chikindas ML (2020) Probiotics at War Against Viruses: What Is Missing from the Picture? Front. Microbiol. 11:1877. doi: 10.3389/fmicb.2020.01877
5 Ichinohe, T., Pang, I., Kumamoto, Y., Peaper, D., Ho, J., Murray, T., et al. (2011). Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc. Natl. Acad. Sci. U.S.A. 108, 5354–5359. doi:10.1073/pnas.1019378108
6 Olaya Galán, N., Ulloa Rubiano, J., Velez Reyes, F., Fernandez Duarte, K., Salas Cárdenas, S., et al. (2016). In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production. J. Appl.Microbiol. 120, 1041–1051. doi: 10.1111/jam.13069
7 Alvarez-Sieiro, P., Montalbán-López, M., Mu, D., and Kuipers, O. P. (2016). Bacteriocins of lactic acid bacteria: extending the family. Appl. Microbiol. Biotechnol. 100, 2939–2951. doi: 10.1007/s00253-016-7343-9
8 Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., and Gordon, J. I. (2007). The human microbiome project. Nature 449, 804–810. doi: 10.1038/nature06244
9 Dobson, A., Cotter, P. D., Ross, R. P., and Hill, C. (2011a). Bacteriocin production: a probiotic trait? Appl. Environ. Microbiol. 78, 1–6. doi: 10.1128/aem.05576-11
10 Gillor, O., Etzion, A., and Riley, M. A. (2008). The dual role of bacteriocins as anti and probiotics. Appl. Microbiol. Biotechnol. 81, 591–606. doi: 10.1007/s00253-008-1726-5
11 Bajaj, B. K., Claes, I. J. J., and Lebeer, S. (2015). Functional mechanisms of probiotics. J. Microbiol. Biotechnol. Food. Sci. 4, 321–327. doi: 10.15414/jmbfs. 2015.4.4.321-327
12 Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., and Ranasinghe, P. (2020). Enhancing immunity in viral infections, with special emphasis on COVID-19: a review. Diabetes Metab. Syndr. 14,367–382. doi: 10.1016/j.dsx.2020.04.015
13 Grasemann, H., Stehling, F., Brunar, H.,Widmann, R., Laliberte, T. W., Molina, L., et al. (2007). Inhalation of Moli1901 in patients with cystic fibrosis. Chest 131, 1461–1466. doi: 10.1378/chest.06-2085
14 Isolauri, E., Sutas, Y., Kankaanpaa, P., Arvilommi, H., and Salminen, S. (2001). Probiotics: effects on immunity. Am. J. Clin. Nutr. 73, 444S–450S. doi: 10.1093/ ajcn/73.2.444s
15 Martin, L. S., McDougal, J. S., and Loskoski, S. L. (1985). Disinfection and inactivation of the human lymphotropic virus type III/lymphadenopathy associated virus. J. Infect. Dis. 152, 400–403. doi:10.1093/infdis/152.2.400
16 de LeBlanc, A. M., Del Carmen, S., Zurita-Turk, M., Santos Rocha, C., Van de Guchte, M., Azevedo, V., et al.(2011). Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases.ISRN Gastroenterol. 2011:892971. doi: 10.5402/2011/892971
17 Fekety R. Guidelines for the diagnosis and management of Clostridium difficile–associated diarrhea and colitis. Am J Gastroenterol 1997;92: 115:1750–3. 739–50.
18 Bartlett JG. Management of Clostridium difficile infection and other antibi-otic-associated diarrhoeas. Eur J Gastroenterol Hepatol 1996;8:1054–61.
19 Francisco Guarner et al, World Gastroenterology Organisation Global Guidelines Probiotics and prebiotics 2017, 1-35
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.