Antibiotic Prophylaxis may Not Significantly Benefit in Preventing Infections in Clean-Wound Surgeries: Study
Researchers found that antibiotic prophylaxis in clean-wound surgeries does not significantly reduce the incidence of surgical site infections (SSIs), with consideration to reevaluate its routine use. A recent retrospective study in Thailand was published in the journal of BMC Surgery. The study was conducted by Mai C. and colleagues. This study aimed to assess the benefit of antibiotic prophylaxis in prevention of SSIs following skin excision, thyroidectomy, inguinal herniorraphy, as well as other breast surgeries.
These were aseptic surgical procedures, which incorporated regional or general anesthesia to be performed for the evaluation of the SSI rates in clean wounds. In this procedure, antibiotic prophylaxis was given at the discretion of the attending surgeons since institution practices vary related to this aspect. Out of the initial list of 501 surgeries, a total number of 417 surgeries were included after excluding the 84 cases based on the reason of incompleteness. Standardized criteria defined SSI, and medical records and reports from the infection control unit were abstracted for data. The study analyzed risk factors for infection by applying propensity score weighting to balance covariates between the groups of patients who received antibiotics and those who did not.
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