Bariatric Surgery May Eliminate Obesity-Related Breast Cancer Risk

Residual hazard of breast cancer after washout periods of 1, 2, and 5 years. Comparisons were made between the surgical and nonsurgical cohorts overall and within each of the BMI subgroups.

Results

In total, 69 260 women were included in the analysis, with 13 852 women in each of the 5 study cohorts.

The mean (SD) age was 45.1 (10.9) years. In the postsurgical cohort vs the overall nonsurgical cohort (n = 55 408), there was an increased hazard for incident breast cancer in the nonsurgical group after washout periods of 1 year , and 5 years .

When the postsurgical cohort was compared with the nonsurgical cohort with BMI less than 25, the hazard of incident breast cancer was not significantly different regardless of the washout period, whereas there was a reduced hazard for incident breast cancer among postsurgical patients compared with nonsurgical patients in all high BMI categories (BMI ≥25).

Findings suggest that bariatric surgery was associated with a reduced risk of developing breast cancer for women with prior obesity equivalent to that of a woman with a BMI less than 25 and a lower risk when compared with all groups with BMI greater than or equal to 25.

Reference:

Doumouras AG, Lovrics O, Paterson JM, et al. Residual Risk of Breast Cancer After Bariatric Surgery. JAMA Surg. Published online April 12, 2023. doi:10.1001/jamasurg.2023.0530