Preoperative administration of LMW heparin safe in lung cancer patients: BMC
Preoperative administration of low-molecular-weight-heparin demonstrates safety and feasibility for lung cancer patients intended to receive minimally invasive surgery,suggests findings from a recently published study in BMC Surgery.
Venous thromboembolism remains a common but preventable complication for cancerous lung surgical patients. Current guidelines recommend thromboprophylaxis for lung patients at high risk of thrombosis, while a consensus about specific administration time is not reached. The current study was designed to investigate the safety profile of preoperative administration of low-molecular-weight-heparin (LMWH) for lung cancer patients. Researchers innovatively designed this study to testify whether preoperative administration of LMWH for lung cancer patients was safe and feasible.
From July 2017 to June 2018, patients prepared to undergo lung cancer surgery were randomly divided into the preoperative LMWH-administration group (PRL) for 4000 IU per day and the postoperative LMWH-administration group (POL) with same dosage, all the patients received thromboprophylaxis until discharge. Baseline characteristics including demographics and preoperative coagulation parameters were analyzed, while the endpoints included postoperative coagulation parameters, postoperative drainage data, hematologic data, intraoperative bleeding volume and reoperation rate.
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