Use of intravenous tranexamic acid not linked to thromboembolic events: JAMA
Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.
Findings from a recent systematic review and meta-analysis of 216 studies suggested that intravenous Tranexamic acid (TXA), irrespective of dosing, is not associated with increased risk of any TE. Authors further concluded "These results help clarify the incidence of adverse events associated with administration of intravenous Tranexamic acid (TXA) and suggest that TXA is safe for use with undetermined utility for patients receiving neurological care." The findings have been put forth in JAMA Surgery.
To have a detailed knowledge, the team of researchers sought to carry out the current study to examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.
For the Data Source, Cochrane Central Register of Controlled Trials and MEDLINE were searched for eligible studies investigating intravenous TXA and postinterventional outcome published between 1976 and 2020. Randomized clinical trials comparing intravenous TXA with placebo/no treatment were selected. The electronic database search yielded a total of 782 studies, and 381 were considered for full-text review. Included studies were published in English, German, French, and Spanish. Studies with only oral or topical tranexamic administration were excluded. Meta-analysis, subgroup and sensitivity analysis, and meta-regression were performed. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline.
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