Antibiotic treatment duration not associated with UTI recurrence in children
USA: Consistent with antimicrobial stewardship efforts, a recent study has found that the duration of antibiotic treatment for uncomplicated urinary tract infection (UTI) is not significantly associated with UTI recurrence in pediatric patients. The findings, published in the Annals of Pharmacotherapy, provide support for shorter-course treatment.
Inconsistencies and gaps in published information about optimal antibiotic treatment duration for uncomplicated UTI in pediatric patients pose a dilemma for antibiotic stewardship. To address this, Titilola M. Afolabi, Midwestern University, Glendale, AZ, USA, and colleagues conducted the study to evaluate the association of antibiotic treatment duration with recurrence rates in children with new-onset cystitis or pyelonephritis.
For the purpose, the authors used the Truven Health MarketScan Database (2013-2015) to obtain data on patients aged 2-17 years with new-onset cystitis or pyelonephritis not caused by a renal or anatomical abnormality.
Key findings of the study include:
· Of 7698 patients, 85.5% had cystitis, 14.3% pyelonephritis.
· Duration of antibiotic treatment was as follows: 3 to 5 days for cystitis (20.4%) or 7 (33.6%), 10 (44.2%), or 14 (1.8%) days for any UTI.
The study, "Association of Antibiotic Treatment Duration With Recurrence of Uncomplicated Urinary Tract Infection in Pediatric Patients," is published in the journal Annals of Pharmacotherapy.
DOI: https://doi.org/10.1177/1060028019900650
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