Aromatase inhibitors safe and effective for treating male infertility, says study

Published On 2022-05-13 03:30 GMT   |   Update On 2022-05-13 07:23 GMT

China: Aromatase inhibitors (AIs) may be effective for the treatment of male infertility, according to a recent study in the journal Andrology. AIs discontinuation for 2-7 days before sperm retrieval may increase the success rate of fertilization for infertile male patients planning assisted reproduction. For decades, aromatase inhibitors has been utilized for treating male fertility....

Login or Register to read the full article

China: Aromatase inhibitors (AIs) may be effective for the treatment of male infertility, according to a recent study in the journal Andrology. AIs discontinuation for 2-7 days before sperm retrieval may increase the success rate of fertilization for infertile male patients planning assisted reproduction. 

For decades, aromatase inhibitors has been utilized for treating male fertility. Still, the safety and efficacy of AIs in the treatment of male infertility remain controversial due to the lack of large-scale randomized controlled studies and basic research. Therefore, there is a need to conduct an evidence-based preliminary evaluation of the existing clinical trials of AIs in the treatment of male infertility.

Considering the above, Jian-guo Liu, Department of Andrology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, China, and colleagues conducted a systematic review with a meta-analysis of all available studies reporting sperm conventional parameters, gonadotropin and testosterone levels, and/or the pregnancy rate. They performed a comprehensive literature search in the PubMed, Embase, Cochrane, CNKI, VIP, CBM, and Wanfang databases through August 2021 for all studies. A total of 10 studies involving 666 patients were included. 

Based on the study, the researchers reported the following findings:

  • Letrozole (LE) or anastrozole (AZ) administration significantly increased sperm concentration, total sperm count, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) levels, and the testosterone-to-estradiol ratio (T/E2), but E2 levels were significantly reduced compared with baseline values.
  • Compared with the control group, which included selective estrogen receptor modulators (SEMRs) or human chorionic gonadotropin (HCG), LE, or AZ did not have any significant effect on sperm concentration, motility, and morphology, except that AIs had less effect on sperm motility than the control group (weighted mean difference [WMD]: −2.55).

To conclude, "AIs may be an effective treatment for male fertility. For infertile male patients planning assisted reproduction, discontinuation of AIs for 2–7 days prior to sperm retrieval may increase the success rate of fertilization."

"Further studies with larger sample sizes are needed to validate these findings," the researchers wrote. 

Reference:

Guo B, Li JJ, Ma YL, Zhao YT, Liu JG. Efficacy and safety of letrozole or anastrozole in the treatment of male infertility with low testosterone-estradiol ratio: A meta-analysis and systematic review. Andrology. 2022 Apr 19. doi: 10.1111/andr.13185. Epub ahead of print. PMID: 35438843.

Tags:    
Advertisement
Article Source : Andrology journal

Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News