Cumulative Androgen Deprivation Therapy paves way to higher risk of Dementia

The link between androgen deprivation therapy (ADT) and dementia in men with prostate cancer is still unclear.

Researchers have found in a new study that exposure to Cumulative androgen deprivation therapy (ADT) increases risk of dementia. Therefore  goal is to reduce the amount of male hormones in the body, known as androgens, or to prevent them from fueling prostate cancer cells.But this needs to be done judiciously.

The findings of this study were published in The Journal of urology on 2nd December, 2021.

Researchers examined the relationship between cumulative ADT exposure and the onset of dementia in a nationwide longitudinal registry of men with prostate cancer in this study.

In this study, the CaPSURE registry was used to conduct a retrospective analysis of men aged 50 years. The primary outcome was the development of dementia following primary treatment. Total ADT exposure was expressed as a time-varying independent variable of ADT exposure. A propensity score was used to estimate the likelihood of receiving ADT. Cox proportional hazards regression was used to determine the relationship between ADT exposure and dementia with competing risk of death in men receiving various treatments, after controlling for propensity score and clinical covariates.