Cytokines released by Clostridium difficile "crucial" to prevent and manage prostate cancer
An original article published in Cureus has concluded that there is a significant novel association between C. difficile and reduced incidence of Prostate Cancer (PC).
Clostridium difficile is a common hospital-acquired infection. It is associated with the release of various cytokines.
It is known that PC is the second most common cancer in men. C. difficile releases proinflammatory cytokines like interleukin (IL)-1β, IL-8, IL-16, and IL-17A, and regulatory and anti-inflammatory cytokines like IL-10, IL-23, and IL-48. The cytokines released may reduce PC development.
There is a possibility that anti-inflammatory and tumoricidal cytokines released by C.difficile infection decrease PC risk.
Considering this background, researchers investigated this relationship using PearlDiver national database. The patients with/without a history of infection were evaluated for PC incidence using the International Classification of Disease Ninth and Tenth Revision codes.
The study summary includes the following:
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