Declining Kidney function linked to cognitive impairment in high BP patients
USA: Declining kidney function in hypertension patients may increase the risk for dementia and mild cognitive impairment (MCI), according to a recent study in the Journal of the American Society of Nephrology.
Intensive hypertension treatment may be beneficial for cardiovascular disease and cognitive function but this comes at the cost of reduced kidney function. Manjula Kurella Tamura, Division of Nephrology, Stanford University School of Medicine, Palo Alto, California, and colleagues investigated markers of kidney function and the effect of intensive hypertension treatment on the incidence of dementia and MCI.
The study included 9361 participants from the randomized Systolic Blood Pressure Intervention Trial -- which compared intensive versus standard systolic BP lowering (targeting <120 mm Hg versus <140 mm Hg, respectively). The participants were categorized according to baseline and longitudinal changes in eGFR and urinary albumin-to-creatinine ratio. Primary outcomes were the occurrence of adjudicated probable dementia and MCI.
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